Central xanthoma of the mandible associated with hyperlipidemia: A rare presentation.

Department of Oncology and Diagnostic Sciences, University of Maryland School of Dentistry, Baltimore, MD, United States. Electronic address: jbrooks@umaryland.edu. Department of Oral and Maxillofacial Surgery, University of Maryland School of Dentistry, Baltimore, MD, United States. Electronic address: bmostoufi@umaryland.edu. Graduate Program in Oral and Experimental Pathology, Department of Oncology and Diagnostic Sciences, University of Maryland School of Dentistry, Baltimore, MD, United States. Electronic address: asultan1@umaryland.edu. Graduate Program in Oral and Experimental Pathology, Department of Oncology and Diagnostic Sciences, University of Maryland School of Dentistry, Baltimore, MD, United States. Electronic address: khouryzh@umaryland.edu. Director of Oral and Maxillofacial Radiology, Department of Oncology and Diagnostic Sciences, University of Maryland Dental School, Baltimore, MD, United States. Electronic address: jbprice@umaryland.edu. Department of Pathology, University of Maryland School of Medicine, Baltimore, MD, United States. Electronic address: jpapadimitriou@som.umaryland.edu. Department of Oncology and Diagnostic Sciences, University of Maryland School of Dentistry, Baltimore, MD, United States; Molecular and Structural Biology Branch, The Marlene and Stewart Greenebaum Center, Baltimore, MD, United States. Electronic address: jbasile@umaryland.edu. Department of Pathology, University of Maryland School of Medicine, Baltimore, MD, United States; Electron Microscopy Laboratory, University of Maryland School of Medicine, Baltimore, MD, United States. Electronic address: cdrac001@umaryland.edu. Department of Oncology and Diagnostic Sciences, University of Maryland School of Dentistry, Baltimore, MD, United States; Molecular and Structural Biology Branch, The Marlene and Stewart Greenebaum Center, Baltimore, MD, United States. Electronic address: ryounis1@umaryland.edu.

International journal of pediatric otorhinolaryngology. 2018;:75-78
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Abstract

Xanthoma is a common, self-limiting cutaneous lesion of non-Langerhans cell, lipid-laden foamy histiocytes that is often concomitant with hyperlipidemia. The intraosseous counterpart is rarely encountered and typically presents as a painless, expansile osteolytic process in the context of hyperlipidemia or normolipidemia. Only a scant number of gnathic xanthomas have been reported in the otolaryngologic literature. We report the clinical, laboratory, radiographic, histopathologic, immunohistochemical, and ultrastructural studies of a mandibular lesion discovered in an asymptomatic 16-year-old male, and associated with 2 previously unreported comorbidities, namely hyperlipidemia and vitamin D deficiency.

Methodological quality

Publication Type : Case Reports

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